Mastocytosis - Causes, Symptoms and Treatment
Definition Mastocytosis is a disorder characterized by mast cell proliferation and accumulation within various organs, most commonly the skin. It is a disorder in both children and adults. It is caused by the presence of too many mast cells in your body. You can find mast cells in skin, linings of the stomach and intestine, and connective tissue. There are three main forms of mastocytosis. In a rare form, mast cells accumulate as a single mass in the skin. Typically, a mastocytoma develops before age 6 months. In a form called urticaria pigmentosa, mast cells accumulate in many areas of the skin, forming small reddish brown spots or bumps. When an UP or M lesion is stroked, it typically urticates, becoming pruritic, edematous, and erythematous. This change is referred to as the Darier sign, which is explainable on the basis of mast cell degranulation induced by physical stimulation. Causes
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